Stadium: Sox Harrison Stadium Round: 1
| NCAAF | 2022/10/01 18:00 | Mercyhurst Lakers v Edinboro Fighting Scots | W | 13-16 |
| NCAAF | 2021/10/16 16:00 | Edinboro Fighting Scots v Mercyhurst Lakers | L | 20-27 |
| NCAAF | 2019/10/12 18:00 | Edinboro Fighting Scots v Mercyhurst Lakers | L | 23-44 |
| NCAAF | 2018/10/06 16:00 | Mercyhurst Lakers v Edinboro Fighting Scots | L | 24-6 |
| NCAAF | 2023/09/23 16:00 | Edinboro Fighting Scots v California Vulcans | L | 10-31 |
| NCAAF | 2023/09/16 18:00 | Bloomsburg Huskies v Edinboro Fighting Scots | W | 13-23 |
| NCAAF | 2023/09/09 16:00 | Edinboro Fighting Scots v Shepherd Rams | L | 28-35 |
| NCAAF | 2023/09/02 16:00 | Duquesne v Edinboro Fighting Scots | L | 49-7 |
| NCAAF | 2022/11/12 17:00 | Edinboro Fighting Scots v Lock Haven | W | 26-13 |
| NCAAF | 2022/11/05 17:00 | Slippery Rock v Edinboro Fighting Scots | L | 28-21 |
| NCAAF | 2022/10/29 16:00 | Edinboro Fighting Scots v Seton Hill Griffins | L | 14-45 |
| NCAAF | 2022/10/22 16:00 | Clarion Golden Eagles v Edinboro Fighting Scots | W | 17-47 |
| NCAAF | 2023/09/23 17:00 | Mercyhurst Lakers v Iup Crimson Hawks | L | 13-30 |
| NCAAF | 2023/09/16 16:00 | Kutztown Golden Bears v Mercyhurst Lakers | L | 47-14 |
| NCAAF | 2023/09/09 22:00 | Mercyhurst Lakers v Lock Haven | W | 41-29 |
| NCAAF | 2023/09/01 00:00 | Ferris State v Mercyhurst Lakers | L | 54-12 |
| NCAAF | 2022/11/12 17:00 | Mercyhurst Lakers v Bloomsburg Huskies | L | 13-16 |
| NCAAF | 2022/11/05 18:00 | Seton Hill Griffins v Mercyhurst Lakers | L | 7-0 |
| NCAAF | 2022/10/29 16:00 | Mercyhurst Lakers v California Vulcans | L | 20-44 |
| NCAAF | 2022/10/22 16:00 | Gannon University Golden Knights v Mercyhurst Lakers | L | 49-14 |