| ITF W40 - Mexico City | 02/02 16:30 | 27 | [337] Emina Bektas v Despina Papamichail [151] | 6-2,4-6,2-6 | |
| ITF W40 - Mexico City | 02/01 17:15 | 26 | [373] Jana Kolodynska v Despina Papamichail [151] | 6-2,3-6,6-7 | |
| ITF W40 - Mexico City | 01/31 20:20 | 25 | Mao Mushika v Despina Papamichail | 2-6,6-4,2-6 | |
| ITF W60 - Sunderland | 01/26 10:00 | 26 | [157] Despina Papamichail v Magali Kempen [211] | 4-6,0-6 | |
| ITF W60 - Sunderland | 01/24 10:00 | 25 | [157] Despina Papamichail v Lena Papadakis [255] | 6-4,7-6 | |
| Australian Open - Kvinder | 01/11 04:45 | 15 | [158] Despina Papamichail v Olga Danilovic [153] | 3-6,1-6 | |
| Australian Open - Kvinder | 01/10 02:05 | 14 | [111] Reka-Luca Jani v Despina Papamichail [158] | 1-6,0-6 | |
| United Cup - Kvinder | 01/07 08:50 | 28 | [158] Despina Papamichail v Lucia Bronzetti [54] | Cancelled | |
| United Cup - Kvinder | 01/04 04:30 | 19 | [158] Despina Papamichail v Donna Vekic [67] | 2-6,0-6 | |
| United Cup - Kvinder | 01/02 04:00 | - | [158] Despina Papamichail v Alison Van Uytvanck [72] | 5-7,6-2,3-6 | |
| United Cup - Kvinder | 12/29 04:00 | - | [158] Despina Papamichail v Isabella Shinikova [381] | 3-6,6-4,6-1 | |
| ITF W80 - Valencia | 11/23 10:20 | 25 | [159] Despina P'michail v Sada Nahimana [265] | 4-6,3-6 | |
| ITF W80 - Madrid | 11/16 10:25 | 25 | [155] Despina Papamichail v Marie Benoit [279] | 3-6,6-7 | |
| WTA - Colina | 11/10 15:00 | 26 | [129] Victoria Jimenez Kasintseva v Despina Papamichail [156] | 6-1,6-2 | |
| WTA - Colina | 11/08 16:25 | 25 | [156] Despina Papamichail v Darya Astakhova [221] | 6-3,6-3 | |
| ITF W60 - Barranquilla | 11/02 17:40 | 25 | Despina Papamichail v Raveena Kingsley | 3-6,6-3,2-6 | |
| ITF W60 - Hamborg | 10/20 14:25 | 26 | [404] Julia Middendorf v Despina Papamichail [143] | 7-6,3-6,6-4 | |
| ITF W60 - Hamborg | 10/19 08:00 | 25 | [390] Veronika Erjavec v Despina Papamichail [143] | 6-3,2-6,3-6 | |
| ITF W60 - Monastir | 10/15 11:55 | 28 | [136] Kristina Mladenovic v Despina Papamichail [152] | 6-2,6-4 | |
| ITF W60 - Monastir | 10/14 09:00 | 27 | [280] Weronika Falkowska v Despina Papamichail [152] | 3-6,6-1,2-6 | |
| ITF W60 - Monastir | 10/13 11:00 | 26 | [237] Isabella Shinikova v Despina Papamichail [152] | 6-3,3-6,6-7 | |
| ITF W60 - Monastir | 10/12 12:15 | 25 | [121] Estelle Cascino v Despina Papamichail [152] | 1-6,3-6 | |
| WTA - Monastir | 10/05 17:00 | 26 | [175] Despina Papamichail v Elise Mertens [42] | 7-5,1-6,2-6 | |
| WTA - Monastir | 10/03 10:00 | 25 | [64] Lin Zhu v Despina Papamichail [175] | 6-1,6-7,0-6 | |
| WTA - Monastir | 10/02 09:00 | 19 | [130] Kristina Mladenovic v Despina Papamichail [175] | 6-2,2-6,4-6 | |
| WTA - Monastir | 10/01 11:50 | 14 | [432] Ines Ibbou v Despina Papamichail [175] | 3-6,2-6 | |
| WTA - Tokyo | 09/21 02:00 | 26 | [213] Despina Papamichail v Garbine Muguruza [12] | 4-6,2-6 | |
| WTA - Tokyo | 09/19 11:20 | 25 | [328] Xiaodi You v Despina Papamichail [213] | 4-6,2-6 | |
| WTA - Tokyo | 09/18 02:00 | 19 | [197] Despina Papamichail v Himeno Sakatsume [357] | 6-2,6-4 | |
| WTA - Tokyo | 09/17 02:30 | 14 | [197] Despina Papamichail v Erika Sema [426] | 6-4,4-6,6-4 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.